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대한내과학회학술지에 실렸던 리뷰 논문에서 실린 figure입니다. 신장의 nephron에서 extracellular vesicle의 역할에 대한 내용을 하나의 그림으로 정리한 일러스트입니다.

 

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Extracellular vesicles in renal physiology and clinical applications for renal disease

Many cells in the nephron release extracellular vesicles (EVs). EVs envelop nucleic acids, proteins, and lipids. The surfaces of EVs express donor cell-specific markers, ligands, and major histocompatibility complex molecules. They are involved in cell-to-cell communication, immune modulation, and the removal of unwanted materials from cells. EVs have been studied as biomarkers of specific diseases and have potential therapeutic applications. Recent research has emphasized the functions of EVs in the kidney. This review provides an overview of recent findings related to the roles of EVs in the nephron, and their utility as biomarkers and therapeutic factors in renal disease.

Korean J Intern Med 2019;34:470-479